Below are links to the topmost of our collection of 4,084+ research reports supporting the benefits of dental probiotics for oral health (and even a couple for intestinal health). Some of the links are web pages and some are PDF downloads.

Fact-checking policy:

As much as possible we use peer-reviewed research from highly trusted sites such as PubMed, PLOS, ADA, CDA, CDC, NIDCR, and Cochrane, which is an independent group of researchers who study various research papers to see if they are indeed valid. We correct errors transparently and swiftly, and learn from mistakes so that they aren’t repeated. If you find an error, email:

Correction policy:

If any of the research is discovered to be invalid, or new research contradicts the old research, we will make corrections accordingly. We check the research monthly and we update as necessary. If new research simply improves upon the old, we will just replace the old research. For corrections, we state the abstract of the prior research, and directly below that, we state what has been corrected with the new research.

Ethics Policy

RENUzORAL’s code of ethics abides by the longstanding values and standards of practice of the journalism profession, such as accuracy, fairness, completeness, honesty, transparency, and integrity. It is inspired by nonprofit and independent news organizations such as ProPublica, and the Center for Investigative Reporting, as well as from professional organizations such as the Education Writers Association and the Society for Professional Journalists.

Possible conflict of interest disclosure:

Dr. Steven Edwards is the developer of a class of oral-adherent dental health products, some of which use probiotic microbes. One such product was “Orchestra Dental Probiotics" which was an oral-adherent, time-release probiotic lozenge, which was placed on the market in 2016. However, when Dr. Edwards realized that an oral-dissolving film would be a better solution, he took the “Orchestra" lozenge off the market in 2017 and devoted two years to developing the oral-dissolving film, “BREATHIFIC Dental Probiotics", which is a safer and easier product to use than a lozenge.

The Research

  1. Novel Anticaries and Remineralization Agents: Future Research Needs;

    Featherstone JD, Fontana M, Wolff M. Novel Anticaries and Remineralization Agents: Future Research Needs. J Dent Res. 2018;97(2):125–127. doi:10.1177/0022034517746371 (…. This report outlines most of what Breathific Dental Probiotics are capable of doing.)

  2. Retrospective Review of Oral Probiotic Therapy;
    Mark L Cannon, Ashlee Vorachek, Catherine Le, Kevin White
    Journal of Clinical Pediatric Dentistry 2019, 43 (6): 367-371

    — This report shows that dental probiotics had a clincially significant effect in suppressing cavities in children.

  3. A pilot study to assess oral colonization and pH buffering by the probiotic Streptococcus dentisani under different dosing regimes — This report states that repeated doses of 5-minute time-release probiotic gels managed to increase the growth of dental probiotics to some extent.
  4. Recovery of Viable Bacteria from Probiotic Products that Target Oral Health — web page — basically states that probiotic organisms must somehow be retained in the mouth and that freeze-dried organisms need to be protected from immunoglobulins

  5. Probiotics for Management of Periodontal Disease: A Novel Therapeutic Strategy? — web page

  6. The Use of Probiotic Strains in Caries Prevention: A Systematic Review — web page

  7. Probiotics for Oral Health: Myth or Reality? — PDF — California Dental Association Journal states that oral health probiotics show promise

  8. Probiotics and the Reduction of Dental Caries Risk — PDF

  9. Probiotics: Contributions to Oral and Dental Health — PDF

  10. Probiotics and Periodontal Disease: A Current Update — PDF

  11. Probiotics for Bacterial Disease Treatment in the Oral Environment — web page

  12. The Role of Streptococcus salivarius as a Modulator of Homeostasis in the Oral Cavity — PDF

  13. Developing Oral Probiotics from Streptococcus salivarius — PDF

  14. University of Florida News — Streptococcus A12 — web page

  15. Porphyromonas gingivalis may be involved with IBD — web page

  16. Porphyromonas gingivalis and ulcerative colitis  — probiotics can reduce inflammation in ulcerative colitis — web page

  17. The Keystone Pathogen Hypothesis  — web page

  18. Several oral lactobacilli, L. acidophilus, L. paracasei, L. brevis and L. fermentum, also possess the fructose pathway and could thus be inhibited by xylitol — web page

  19. Oral bacteria: How many? How fast?

Our probiotics and their targets:

Coming soon. Information is currently classified.

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